Fixed drug eruption by etoricoxib confirmed by patch test

Abstract: Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. We describe the case of a 74-year-old woman with numerous, rounded, erythematous lesions on the trunk and recurrent blistering on the fifth right-hand finger, which developed a few hours after taking etoricoxib. Lesional patch testing with etoricoxib was positive and reproduced the typical pattern of a fixed drug eruption upon histopathology. We emphasize the specific reactivity of the etoricoxib patch test, and the capacity to reproduce the histologic pattern of the reaction.

Acute generalized exanthematous pustulosis x Von Zumbusch’s pustular psoriasis: A diagnostic challenge in a psoriatic patient

AbstractSevere cutaneous drug reactions include a wide spectrum of clinical manifestations ranging from mild morbilliform cutaneous rash, to severe forms of hypersensitivity. Special attention is given in this report to the acute generalized exanthematous pustulosis (AGEP), induced in 90% of cases by the use of systemic drugs, especially aminopenicillins and macrolides. The incidence of the disease is low, 1-5 cases per million patients / year. The main differential diagnosis is Von Zumbusch's Pustular Psoriasis. The prognosis is generally good and the disease self limited, after withdrawal of the triggering drug. In this report the authors describe a case of AGEP, triggered by ceftriaxone in a patient with psoriasis vulgaris.

Fibroqueratoma digital adquirido: a propósito de um caso clínico / Acquired digital fibrokeratoma: report on a clinical case of a clinical case

O fibroqueratoma digital adquirido é tumor fibroepitelial benigno, raro, que, tipicamente, se apresenta como nódulo solitário assintomático nos quirodáctilos e pododáctilos. Relata-se o caso clínico de uma paciente do sexo feminino que apresentava duas lesões de fibroqueratoma digital no quarto e no segundo quirodáctilos esquerdos.

Acquired digital fibrokeratoma is a rare benign fibroepithelial condition, which typically occurs as a solitary asymptomatic nodule in fingers and toes. The authors report the clinical case of a female patient affected by two digital fibrokeratomas in the 4th and 2nd left fingers, respectively.